Synthesis of tetrahydrobenzo[b]pyran and 3,4-dihydropyrimidinone derivatives using glutamic acid as an efficient catalyst

ABSTRACT

The efforts to use green catalysts for organic synthesis are undeniable. Natural catalysts are biodegradable and easy to access. Herein, glutamic acid was applied as a natural and green catalyst for the synthesis of tetrahydrobenzo[b]pyran and 3,4-dihydropyrimidinone derivatives under solvent-free and thermal conditions. The most advantages of this research are use of natural, green, and biodegradable catalyst; easy work-up; and high yields.

KEYWORDS:

• Glutamic acid
• tetrahydrobenzo[b]pyran
• 3,4-dihydropyrimidinone
• solvent-free and thermal conditions

Funding

Financial support from the Research Council of the Islamic Azad University, Zahedan Branch is gratefully acknowledged.