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Articles

Bis(pyridazine-5-olate-4-carboxylate)manganese hydrate: Synthesis, characterization, and in vitro antitumor activities

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Pages 703-707 | Received 25 Dec 2015, Accepted 09 Jul 2016, Published online: 17 Aug 2016
 

ABSTRACT

New complex of Mn(C5H4N2O3)2(H2O)2·H2O (1) where C5H4N2O3 is pyridazine-5-olate-4-carboxylate (HPZOC) has been prepared by hydrothermal reaction and structurally characterized by X-ray single-crystal diffraction analysis, FT-IR spectroscopy, elemental analysis, and thermogravimetric analyses. In complex 1, each Mn2+ ion is six-coordinated by six O atoms with chelating mode from the two HPZOC ligands and two water molecules. It was found that complex 1 exhibits good inhibition of the proliferation of MCF-7 and HeLa cells in vitro. Furthermore, the cell apoptosis of complex 1 against MCF-7 cells is detected by Annexin V/propidium iodide flow cytometry.

Funding

This work was supported by grants from the Domestic Senior Visiting Scholar Funded Projects of Jiangsu Province (2014FX007), Jiangsu Overseas Research & Training Program for University Prominent Young & Middle-aged Teachers and Presidents (2015), and Industry Academic Research Prospective Joint Research Project of Jiangsu Province (BY2015032-01).

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