Microwave-assisted synthesis of triamide derivatives via a pseudo five-component one-pot reaction

ABSTRACT

The reaction between Meldrum's acid and aryl aldehydes with alkyl isocyanides in the presence of two equivalents of aniline in microwave conditions provided a simple and efficient one-pot route for the synthesis of triamide derivatives in good yields. The present method does not involve any hazardous organic solvent. Therefore, this procedure could be classified as green chemistry.

KEYWORDS:

• Microwave conditions
• Meldrum's acid
• alkyl isocyanides
• aryl aldehydes
• triamide derivatives
• green chemistry

Funding

Financial support from the Research Council of the Islamic Azad University, Zahedan Branch is gratefully acknowledged.