Synthesis, spectroscopic characterization, crystal structure, and biological evaluation of a diorganotin(IV) complex with 2-acetylpyridine N⁴-cyclohexylthiosemicarbazone

ABSTRACT

The diorganotin(IV) complex [Ph₂Sn(L)(OAc)]·EtOH (1), where HL = 2-acetylpyridine N⁴-cyclohexyl thiosemicarbazone, has been synthesized and characterized by elemental analysis, IR, UV–vis, NMR, PL, and mass spectrometry. The crystal structure was characterized by X-ray diffraction method. Tin(IV) ion is coordinated by one L⁻ anion through pyridine nitrogen, azomethine nitrogen and sulfur atom, two phenyl groups, and one OAc⁻ anion through two carboxyl oxygen atoms building a distorted pentagonal bipyramid. Biological studies showed that 1 exhibited lower IC₅₀ value 3.32 ± 0.52 μM against HepG2 cells, compared to the free ligand. In addition, complex 1 also exhibited excellent luminescent property.

KEYWORDS:

• Thiosemicarbazone
• diorganotin(IV)
• crystal structure
• cytotoxicity

Funding

This work was financially supported by the National Natural Science Foundation of China and the Natural Science Foundation of the Educational Department of Henan Province (14B150028).