Synthesis and Characterization of Some First Row Transition Metal Complexes of 4-Amino-N-(5-methyl-3-isoxazolyl-benzenesulfonamide (Sulfamethoxazole)

Abstract

Sulfamethoxazole has been shown to form complexes with Cr(III), Mn(II), Fe(III), Ni(II), Cu(II) and Zn(II). The solid complexes isolated were characterized by conductivity measurement, elemental analysis and magnetic, spectral (UV-Visible, IR, and ¹H NMR) and thermal studies. Sulfamethoxazole behaves as a monobasic bidentate ligand, binding the metal ion through deprotonated sulfonamide nitrogen and sulfonyl oxygen or isoxazole ring nitrogen.