MAGAM II – prospective observational multicentre poisons centres study on eye exposures caused by cleaning products

Abstract

Objective: Local effects on the eye following cleaning product exposures are frequently reported. According to EU chemicals legislation many cleaning products are labelled with Hazard Phrase 318 indicating risk of irreversible eye damage. The objectives of this study were to identify cleaning products with potential for irreversible eye damage by collecting human exposure data from poisons centres (PC), and to clarify to what degree exact product identification is possible during a PC telephone call.

Methods: MAGAM II was a multicentre binational prospective observational PC study. All human eye exposures to detergents or maintenance products reported to nine PCs taking calls from the public and medical professionals during an 18-month period were included. The severity of eye effects was rated according to the WHO Poisoning Severity Score.

Results: Five hundred and eighty-six cases were included. Product identification by name leading to formula information was successful in 533 cases (91%). Follow-up was successful in 528 exposures. Irrigation was performed in 94% of cases. Duration of symptoms was ≥24 hours in 73 patients (25%). 33 (6%) patients developed moderate eye injury. Healing was reported in all cases. The percentage of moderate cases was highest in the group of drain cleaners (25%), toilet cleaners (18%) and oven cleaners (15%). Products intended for professional use caused relatively more moderate eye injuries than products also intended for consumer use.

Conclusion: MAGAM II has shown that PCs are able to identify formulas in sufficiently high quality as needed for product-directed toxicovigilance. The results underline the potential of PC exposure case data for product safety monitoring. The results indicate that irreversible eye damage is very rare after cleaning product exposure.

Keywords:

• Chemical eye injury
• product categories
• product identification
• cleaning products
• EU chemicals legislation

Acknowledgements

The authors thank the German Cosmetics, Toiletry, Perfumery and Detergent Association (IKW) for funding the Study and for support in product categorisation.

Disclosure statement

The German Cosmetics, Toiletry, Perfumery and Detergent Association (IKW) funded this study. IKW experts reviewed categorisation of registered products but did not influence data acquisition, data interpretation or data analysis.

No other potential conflict of interest was reported by the authors.

Additional information

Funding

The German Cosmetics, Toiletry, Perfumery and Detergent Association (IKW) funded this study via a contract with the German Speaking Society of Clinical Toxicology (GfKT).