Extracorporeal membrane oxygenation use in poisoning: a narrative review with clinical recommendations

Abstract

Context

Poisoning may lead to respiratory failure, shock, cardiac arrest, or death. Extracorporeal membrane oxygenation (ECMO) may be used to provide circulatory support, termed venoarterial (VA) ECMO; or respiratory support termed venovenous (VV) ECMO. The clinical utility of ECMO in poisoned patients remains unclear and guidelines on its use in this setting are lacking.

Objectives

To perform a literature search and narrative review on the use of ECMO in poisonings. Additionally, to provide recommendations on the use of ECMO in poisonings from physicians with expertise in ECMO, medical toxicology, critical care, and emergency medicine.

Methods

A literature search in Ovid MEDLINE from 1946 to October 14, 2020, was performed to identify relevant articles with a strategy utilizing both MeSH terms and adjacency searching that encompassed both extracorporeal life support/ECMO/Membrane Oxygenation concepts and chemically-induced disorders/toxicity/poisoning concepts, which identified 318 unique records. Twelve additional manuscripts were identified by the authors for a total of 330 articles for screening, of which 156 were included for this report.

Narrative literature review

The use of ECMO in poisoned patients is significantly increasing over time. Available retrospective data suggest that patients receiving VA ECMO for refractory shock or cardiac arrest due to poisoning have lower mortality as compared to those who receive VA ECMO for non-poisoning-related indications. Poisoned patients treated with ECMO have reduced mortality as compared to those treated without ECMO with similar severity of illness and after adjusted analyses, regardless of the type of ingestion. This is especially evident for poisoned patients with refractory cardiac arrest placed on VA ECMO (termed extracorporeal cardiopulmonary resuscitation [ECPR]).

Indications

We suggest VA ECMO be considered for poisoned patients with refractory cardiogenic shock (continued shock with myocardial dysfunction despite fluid resuscitation, vasoactive support, and indicated toxicologic therapies such as glucagon, intravenous lipid emulsion, hyperinsulinemia euglycemia therapy, or others), and strongly considered for patients with cardiac arrest in institutions which are structured to deliver effective ECPR. VV ECMO should be considered in poisoned patients with ARDS or severe respiratory failure according to traditional indications for ECMO in this setting.

Contraindications

Patients with pre-existing comorbidities with low expected survival or recovery. Relative contraindications vary based on each center’s experience but often include: severe brain injury; advanced age; unrepaired aortic dissection or severe aortic regurgitation in VA ECMO; irreversible organ injury; contraindication to systemic anticoagulation, such as severe hemorrhage.

Conclusions

ECMO may provide hemodynamic or respiratory support to poisoned patients while they recover from the toxic exposure and metabolize or eliminate the toxic agent. Available literature suggests a potential benefit for ECMO use in selected poisoned patients with refractory shock, cardiac arrest, or respiratory failure. Future studies may help to further our understanding of the use and complications of ECMO in poisoned patients.

Keywords:

• ECMO
• ECLS
• ECPR
• poisoning
• overdose
• toxin
• shock
• respiratory failure
• cardiac arrest

Acknowledgments

We thank Andrew Hamilton, MS, MLS, Assistant Professor of Health Science and Senior Reference Librarian, Oregon Health and Science University, for his help in conducting the database search for literature review, as well as his contribution to the methodology. We also thank L. J. Wismann-Horther, BFA, for her help in creating Figure 1 with the aid of BioRender.com.

Disclosure statement

Dr. Brodie is the President-elect of Extracorporeal Life Support Organization (ELSO), receives research support from ALung Technologies, and has been on the medical advisory boards for Baxter, Abiomed, Xenios, and Hemovent. Dr. MacLaren is the Executive Officer, Board of Directors for ELSO. Dr. Zakhary is the Chair of Education and Logistics for ELSO. Drs. Blumenberg, Hendrickson, and Upchurch have no disclosures of interest to declare.