129
Views
12
CrossRef citations to date
0
Altmetric
ArticlesCritical Care

Serum total antioxidant statuses of survivors and nonsurvivors after acute paraquat poisoning

, , , &
Pages 226-229 | Received 20 Feb 2008, Accepted 12 Jun 2008, Published online: 07 Apr 2009
 

Abstract

Introduction. The plasma paraquat (PQ) concentration is an excellent prognostic indicator. However, at the bedside, it is difficult to predict survivors even with known PQ concentrations. We examined the association of total antioxidant status (TAS) in serum to clinical outcome in patients with acute PQ intoxication. Methods. After acute PQ intoxication, 296 patients were admitted to the Institute of Pesticide Poisoning, Soonchunhyang University Cheonan Hospital, from January through December 2007. Serum total antioxidant levels in emergency department were compared between a survivor group and a nonsurvivor group. Results. Age, the amount of PQ ingested, plasma PQ concentration, leukocyte count, blood urea nitrogen (BUN), serum creatinine, uric acid, aspartate aminotransferase, alanine aminotransferase (ALT), and amylase in the emergency department were individually associated with the clinical outcome (p < 0.001), but TAS was not. Multiple logistic regression found the odds ratio (95% confidence interval) to be 10.79 (3.45–33.74) for plasma PQ concentration, but 0.43 (0.02–8.52) for TAS in serum. TAS was not associated with survival. Conclusion. TAS in serum was not a significant influence on the clinical outcome in patients with acute PQ intoxication.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.