Assessment of short-term outcomes following unintentional ingestions of “oral contraceptive pills” by toddlers

Abstract

Background. Cases of unintentional pediatric ingestions of oral contraceptive pills are commonly reported to Poison Information Centers (PICs). No study had examined clinical outcomes in the past 30 years, although the hormone content of these preparations has been substantially reduced. We assessed short-term outcomes to determine the relevance of advice provided, particularly that vaginal bleeding can occur. Methods. Prospective observational study of cases reported to a state PIC were followed up over a 5-month period. Results. There were 63 cases with complete follow-up, average age was 2 years and 10 months; 65% of the patients were female. Median number of pills ingested was 5.0 [Interquartile Range (IQR) 3–16.5]. Minor symptoms including vomiting and irritability were reported in 44% of cases. No case of vaginal bleeding was reported. Conclusion. No major clinical effects and no instances of vaginal bleeding were reported.

Keywords:

• Acute poisoning
• Pediatric
• Poisoning
• Poison control centers
• Poisoning management

Acknowledgments

We are grateful to the staff of the WAPIC for their efforts in recruitment and to Mr Klaus Auert, B.Pharm. for the German translation.