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Abstract
Background
It is seen that various forms of retinoids have different results on VEGF-A and VEGF-C levels when tested at different dosages, in different diseases and under different conditions such as in vivo or in vitro.
Objective
To evaluate the effects of isotretinoin on VEGF-A and VEGF-C levels in humans.
Methods
Blood samples at the third month of the patient group and blood samples of the control group were compared in terms of VEGF-A and VEGF-C concentrations.
Results
No statistically significant difference was observed between the patient group and the control group in terms of VEGF-A and VEGF-C levels.
Limitations
Most of the patients discontinued treatment and could not reach the required number, the study was converted to case–control.
Conclusions
We think that 0.5 mg/kg/day isotretinoin has no effect on blood concentrations of VEGF-A and VEGF-C in humans. Therefore, there is a need for studies using isotretinoin in different doses and durations in humans in order to better evaluate its effects.
Ethical approval
Reviewed and approved by University of Health Sciences; approval #08.02.2019/219.
Disclosure statement
No potential conflict of interest was reported by the author(s).