Effect of rutin on proinflammatory cytokines and oxidative stress in toxin-mediated hepatotoxicity

Abstract

The present study was designed to evaluate the effect of rutin (RT) on lead (Pb)-induced oxidative stress. Rats were divided into groups and were treated with RT with or without lead. Levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and interleukin-1β (IL-1β) were evaluated. Levels of AST, ALT, TNF-α, IL-6, and IL-1β were significantly decreased, and the activities of antioxidant enzymes were increased in the liver of rats treated with RT along with Pb. Histologic changes were improved to almost a normal hepatic structure. The results suggest that RT controls the damaged antioxidant status in Pb-induced oxidative stress.

Keywords:

• Lead
• rutin
• antioxidant enzymes
• hepatotoxicity

Disclosure statement

The authors declare no conflict of interest.

Additional information

Funding

The authors extend their appreciation to the Deanship of Scientific Research, King Saud University, for funding this work through the Undergraduate Student Research Support Program (grant No. USRSP-17-71). Authors also thank Ms. Jocelyn Palao for her help in the preparation of histological samples.