Abstract
Combined exposure to multi-walled carbon nanotubes (MWCNTs) and air contaminants such as benzo [a] pyrene (BaP) in ambient air is unavoidable. In this study, the toxicity of co-exposure to pristine-MWCNTs (P-MWCNTs) and BaP and co-exposure to functionalized-MWCNTs (F-MWCNTs) and BaP were investigated in the A549 lung cells. Combined toxicity demonstrated that co-exposure to P-MWCNTs and BaP had an additive and a synergistic effect through cell viability and ROS generation, respectively. Moreover, our findings indicated that co-exposure to F-MWCNTs and BaP had a slight antagonistic effect on both cell viability and generation of ROS. The results of this study revealed that MWCNTs can alter the toxicity of contaminants such as BaP in the co-exposure situations.
Acknowledgements
This research was part of PhD thesis (first author) at Shahid Beheshti University of Medical Sciences. We would also like to express our gratitude to Professor Motamedi and Professor Ahmadiani from the Neuroscience Research Center of Shahid Beheshti University of Medical Sciences for their cooperation in this project.
Disclosure statement
No potential conflict of interest was reported by the authors.