Kidney inflammation and tissue injury induced by scorpion venom: comparison with a nephrotoxic model

Abstract

The effect of Androctonus australis hector (Aah) venom in comparison with nephrotoxic model was investigated in vivo. Aah venom induced a rapid inflammatory response characterized by recruitment of neutrophil and eosinophil cells, increased levels of cytokines, and lipid peroxidation. These results were in accordance with the histological findings showing structural damage in the nephrons, similar and faster to that induced by cisplatin model. The modifications in renal function parameters as an elevation of blood urea and creatinine levels with a significant increase in the serum aspartate aminotransferase and lactate dehydrogenase were indicative of tissue damages responsible for the renal failure.

Keywords:

• Scorpion venom
• cisplatin
• inflammation
• nephrotoxicity
• kidney

Disclosure statement

The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.