Beneficial effect of low dose gamma irradiation or quercetin on Cerastes cerastes snake venom induced toxicity in male rats

Abstract

This study aimed to evaluate the role of low dose gamma irradiation (IRR) on snake venom induced toxicity in male rats using quercetin as a reference antioxidant. Sixty rats were divided equally into six groups. Control, Venom, IRR, Quercetin, Venom + IRR, and Venom + Quercetin. Serum liver and kidney functions were ameliorated after treatments, as well as, Paroxonase and superoxide dismutase activities, nitric oxide, malondialdehyde, and tumor necrosis factor α levels in liver and kidney tissues also NF-kB gene expression in tissues. Moreover, histopathological study confirmed these improvements. Thus, low dose IRR as well as quercetin was found to be a reliable tool in the treatment of snakebites.

Keywords:

• Cerastes cerastes
• venom toxicity
• low dose irradiation
• quercetin

Correction Statement

This article has been republished with minor changes. These changes do not impact the academic content of the article.

Acknowledgements

The authors are very grateful to Dr/Ahmed osman (Professor of Histopathology, Faculty of Veterinary Medicine, Cairo University, Egypt) for his assistance in examining and interpreting histopathologic aspects of this work.

Disclosure statement

The authors declare that they have no conflict of interest. This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.