Protective role of heptamethoxyflavone on LPS-induced hepatotoxicity

Abstract

Sphaeranthus amaranthoides is well known and reported for its hepatoprotective activity. In this study, an attempt has been made to investigate the hepatoprotective activity of Heptamethoxyflavone isolated from Sphaeranthus amaranthoides. The results obtained in this study showed an increased microbial load of 0.134 ± 0.011 CFU in the high-fructose corn syrup (HFCS) treated group and 0.066 ± 0.003 CFU and LPS in the HFCS–heptamethoxyflavone (HMF)-treated group. On the other hand, the serum ALT, ALP, and ASP and MDA values have significantly decreased when treated with Heptamethoxyflavone. The antioxidant enzyme content was significantly increased in HFCS– heptamethoxyflavone treated rats. In addition, the production levels of caspase-3 and-9, Bcl-2, Bax, IL-β, TNF-α, and NF-κB in the liver are lowered significantly in the HFCS-HMF treated group.

Keywords:

• LPS
• HFCS
• heptamethoxyflavone
• inflammation
• liver

Acknowledgements

The authors thank management of Sathyabama Institute of Science and Technology, Chennai for continuous encouragement and providing space to carry out the research work.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Correction Statement

This article has been republished with minor changes. These changes do not impact the academic content of the article.

Additional information

Funding

This work was supported by DRDO-Life Science Research Board [Grant no DRDO-LSRB-348].