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Cellular targets and molecular activity mechanisms of bee venom in cancer: recent trends and developments

Ayşegül Varola Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Mainz, Germany

Serap Sezenb Sabanci University Nanotechnology Research and Application Center (SUNUM), Istanbul, Turkey;c Faculty of Engineering and Natural Science, Sabanci University, Istanbul, Turkey

Dilhan Evcimend Department of Molecular Biology and Genetics, Faculty of Science, Kotekli Campus, Mugla Sitki Kocman University, Mugla, Turkey

Atefeh Zarepoure Department of Biomedical Engineering, Faculty of Engineering and Natural Sciences, Istinye University, Istanbul, Turkey

Gönül Ulusf Department of Biology, Faculty of Science, Ege University, Izmir, Turkey

Ali Zarrabie Department of Biomedical Engineering, Faculty of Engineering and Natural Sciences, Istinye University, Istanbul, Turkey

https://orcid.org/0000-0003-0391-1769

Gamal Badrg Department of Zoology, Faculty of Science, Laboratory of Immunology, Assiut University, Assiut, Egypt

Sevgi Durna Daştanh Department of Biology, Faculty of Science, Sivas Cumhuriyet University, Sivas, Turkey

Asya Gülistan Orbayoğlud Department of Molecular Biology and Genetics, Faculty of Science, Kotekli Campus, Mugla Sitki Kocman University, Mugla, Turkey

Zeliha Selamoğlui Department Medical Biology, Faculty of Medicine, Nigde Ömer Halisdemir University, Nigde, Turkey

Mehmet Varold Department of Molecular Biology and Genetics, Faculty of Science, Kotekli Campus, Mugla Sitki Kocman University, Mugla, TurkeyCorrespondence[email protected] [email protected]

https://orcid.org/0000-0003-2565-453X

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Abstract

Bee venom therapy is known as a traditional approach to curing many medical conditions such as arthritis, pain and rheumatism. Bee venom also provides promising potential for treating many cancers such as breast, lung, ovary, stomach, kidney, prostate, cervical, colon and esophageal cancers, osteosarcoma, leukemia, melanoma and hepatocellular carcinoma. We therefore focused not only on the molecular activity mechanisms and cellular targets of bee venom and its components, but also on modern solutions as cutting-edge nanotechnological advances to overcome existing bottlenecks, and the latest advances in the anticancer application of bee venom in clinical settings.

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Acknowledgements

We are grateful for PhD stipend of the Turkish Government to A.V.

Disclosure statement

No potential conflict of interest was reported by the author(s).

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Cellular targets and molecular activity mechanisms of bee venom in cancer: recent trends and developments

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Cellular targets and molecular activity mechanisms of bee venom in cancer: recent trends and developments

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