The m6A epitranscriptome opens a new charter in immune system logic

ABSTRACT

N6-methyladenosine (m6A), the most prevalent RNA internal modification, is present in most eukaryotic species and prokaryotes. Studies have highlighted an intricate network architecture by which m6A epitranscriptome impacts on immune response and function. However, it was only until recently that the mechanisms underlying the involvement of m6A modification in immune system were uncovered. Here, we systematically review the m6A involvement in the regulation of innate and adaptive immune cells. Further, the interplay between m6A modification and anti-inflammatory, anti-viral and anti-tumour immunity is also comprehensively summarized. Finally, we focus on the future prospects of m6A modification in immune modulation. A better understanding of the crosstalk between m6A modification and immune system is of great significance to reveal new pathogenic pathways and to develop promising therapeutic targets of diseases.

Keywords:

• N6-methyladenosine
• Immune system
• Anti-inflammatory immunity
• Anti-viral immunity
• Anti-tumour immunity

Acknowledgments

ZHM, XFX and JFJ developed the concept. ZHM, XYG and YS reviewed the literature, wrote the manuscript and prepared the tables and figures. JFJ and XFX provided the full guidance. All authors read and approved the final manuscript.

Disclosure statement

The authors report no conflict of interest.

Additional information

Funding

This study was supported by Innovation Fund for Outstanding Doctoral Candidates of Peking University Health Science Center (Grant number: 71013Y2029).