A two-stage adaptive allocation design for survival outcome with informative censoring

ABSTRACT

An adaptive two-stage allocation design is developed for survival responses subject to independent informative censoring. The asymptotic p value of a score test related to a hypothesis of treatment effectiveness is used to set the assignment probability of the second stage. Several characteristics of the design and the follow-up inference are studied, both numerically and theoretically, and are compared with those of an existing competitor. Applicability of the proposed design is also illustrated through a real data.

KEYWORDS:

• Clinical trials
• two-stage allocation
• informative censoring

AMS SUBJECT CLASSIFICATION:

• 62L05

Acknowledgments

The authors thank the anonymous reviewer, the editor, and the associate editor for their efforts to improve the submitted version of the work.