Synthesis, characterization, and evaluation of differently sulfonated resins as novel carriers for drug delivery

Abstract

The 2-methacryloxyacetophenone (MAP) was prepared and subjected to suspension polymerization with divinylbenzene (DVB). The differently sulfonated MAP–DVB cross-linked copolymer cationic exchange resins were prepared by sulfonation with a fixed volume of concentrated sulfuric acid in an oil bath at 70 ^oC. Several characteristics of the prepared resins were evaluated, i.e. Fourier transform infrared spectra, the ion-exchange capacity, and microscopic morphology. The resin characteristics were altered with degree of sulfonation, providing that differently sulfonated resins could be prepared. The behavior of Fexofenadine hydrochloride loading and in vitro release in the USP stimulated gastric and intestinal fluids of the obtained resins were evaluated. The drug loaded in the resin increased with increasing degree of sulfonic group and hence the drug binding site in resin employed. The drug release was lower from the resins with higher degree of sulfonic group due to the increase in the diffusive path depth. The drug release was a little lower in stimulated gastric fluid (SGF) than stimulated intestinal fluids. The basic group, ionized to a little greater extent in SGF and preferred binding with the resin rather than releasing. Hence, the differently sulfonated resins could be utilized as novel carriers for drug delivery.

Keywords:

• 2-methacryloxyacetophenone
• divinylbenzene
• different sulfonation
• cationic exchange resins
• fexofenadine hydrochloride
• drug release

Acknowledgments

The authors wish to thank The University Grants Commission, New Delhi for its funding of this work, Indian Institute of science Bangalore, for its instrumental support and Department of Physics, Sri Venkateswara University, Tirupathi, for its assistance in the SEM study. The authors also thank UGC, New Delhi for its support under SAP and DST, New Delhi for its support under FIST.