Inflammation in deep vein thrombosis: a therapeutic target?

ABSTRACT

Deep vein thrombosis is a common disease associated with a variety of complications including post-thrombotic syndrome as a late complication. It is now clear that in addition to classical deep vein thrombosis triggers such as blood flow disturbance, hypercoagulability, and vessel wall changes, inflammation has a key role in the pathophysiology of deep vein thrombosis, and there is a close relationship between inflammation and coagulation. As attested by changes in several plasma biomarkers, inflammation may have a significant role in the development of post-thrombotic syndrome. Here, we review the link between inflammation and deep vein thrombosis and thus the potential value of anti-inflammatory and/or anticoagulant drugs in the treatment of deep vein thrombosis and the prevention of post-thrombotic syndrome.

KEYWORDS:

• Deep vein thrombosis
• inflammation
• post-thrombotic syndrome
• DOAC
• heparin
• neutrophil extracellular traps (NETs)
• P-selectin
• CRP

Disclosure statement

No potential conflict of interest was reported by the authors.

ORCID

Delphine Borgel http://orcid.org/0000-0002-8847-8935

Elsa Bianchini http://orcid.org/0000-0002-1370-5312

Dominique Lasne http://orcid.org/0000-0001-6600-0263

François Saller http://orcid.org/0000-0001-5255-2630