Articles
1 Effect of iron chelation therapy on EPO-STAT5 signalling pathway and EPO resistance in iron-overloaded low-risk myelodysplastic syndrome patients
Yao Zhang
11 T-lymphocyte subsets and Th1/Th2 cytokines in convalescent patients with Epstein–Barr virus-associated aplastic anemia
Tingting Chen, Yimin Chen, Wenting Bao and Wei Lu
17 Pharmacokinetics and pharmacodynamics of a recombinant fusion protein linking activated coagulation factor VII with human albumin (rVIIa-FP) in patients with congenital FVII deficiency
Britta Laros-van Gorkom, Pål André Holme, Christine Joch, Tobias Rogosch, Annette Feussner, William McKeand, John Roberts and Waander van Heerde
26 Anemia in centenarians: prevalence and association with kidney function
Wangping Jia, Shengshu Wang, Miao Liu, Shanshan Yang, Wenzhe Cao, Ke Han and Yao He
Letter to the Editor
34 A sporadic MYH9-related disease in a Chinese boy with p.A95T mutation
Wenchao Zhang, Xiaoqiang Lian, Yifeng Sun and Jihong Hao
Article
37 Investigation on glucocorticoid receptors within platelets from adult patients with immune thrombocytopenia
Kam Chau Yung, Cheng Wei Xu, Ze Wen Zhang, Wen Jun Yu, Qian Li, Xian Ru Xu, Ya Fei Han, Xin Jia Wang and Jun Yin
Case Report
43 Donor CMV-specific cytotoxic T lymphocytes successfully treated drug-resistant cytomegalovirus encephalitis after allogeneic hematopoietic stem cell transplantation
Peng Ke, Xiebing Bao, Jihao Zhou, Xiaoli Li, Juan Zhuang, Xuefeng He, Depei Wu, Xinyou Zhang and Xiao Ma
Articles
48 Epidemiology of aplastic anemia: a study of 1324 cases
Parvez Ahmed, Qamar un Nisa Chaudhry, Tariq Mahmood Satti, Syed Kamran Mahmood, Tariq Ghafoor, Nighat Shahbaz, Mehreen Ali Khan, Humayoon Shafique Satti, Zaineb Akram and Raheel Iftikhar
55 Distribution of sickle cell disease and assessment of risk factors based on transcranial Doppler values in the Gulf region
Yasser Wali, Vishwanatha Kini and Mohamed A. Yassin
63 Direct oral anticoagulants for thromboprophylaxis in ambulatory patients with cancer
Yiwei Wang, Maoyun Wang, Yuenan Ni and Zongan Liang
71 The target hemoglobin content values of reticulocytes for efficient anemia improvement are achieved by low ferritin levels and moderate transferrin saturation: a retrospective observational study
Chie Ogawa, Ken Tsuchiya, Naohisa Tomosugi, Katsunori Shimada, Fumiyoshi Kanda and Kunimi Maeda
79 Clinical features and prognosis of normal karyotype acute myeloid leukemia pediatric patients with WT1 mutations: an analysis based on TCGA database
Jing Xu, Yaofang Zhang, Jinjun Hu, Yan Ren and Hongwei Wang
85 The relationship between interferon-gamma (INF-γ) single nucleotide polymorphism +874(T/A) and occurrence risk of aplastic anemia: a meta-analysis
Shu Deng, Shenyun Lin, Jianping Shen and Yuqing Zeng
91 Students’ knowledge on sickle cell disease in Kisangani, Democratic Republic of the Congo
Paul Kambale-Kombi, Roland Marini Djang’eing’a, Jean-Pierre Alworong’a Opara, Serge Tonen-Wolyec, Charles Kayembe Tshilumba and Salomon Batina-Agasa
95 Physical exercise is safe and feasible in thrombocytopenic patients with hematologic malignancies: a narrative review
Shinichiro Morishita, Jiro Nakano, Jack B. Fu and Tetsuya Tsuji
Rapid Communication
101 A novel compound heterozygous mutation in DGKE in a Chinese patient causes atypical hemolytic uremic syndrome
Jitong Li, Yinsen Song, Yaodong Zhang, Hongjiang Li, Ming Tian, Di Li, Shufeng Zhang, Guanghai Cao and Cuihua Liu
Letter to the Editor
108 The safety of modern intravenous iron infusions in patients with rheumatoid arthritis – a review of the literature
Michael Ooi, Stephen Hibbs and Frederick E. Chen
Articles
112 Effects of ibrutinib on in vitro platelet aggregation in blood samples from healthy donors and donors with platelet dysfunction
Joi Ninomoto, Ahmad Mokatrin, Taisei Kinoshita, Carol Marimpietri, Terrance D. Barrett, Betty Y. Chang, Juthamas Sukbuntherng, Danelle F. James and Mark Crowther
118 WT1 overexpression predicted good outcomes in adult B-cell acute lymphoblastic leukemia patients receiving chemotherapy
Shujuan Wang, Chong Wang, Tao Li, Weiqiong Wang, Qianqian Hao, Xinsheng Xie, Dingming Wan, Zhongxing Jiang and Yanfang Liu
125 Pre-transplant sTIM-3 levels may have a predictive impact on transplant outcome in acute leukemia patients
Zeynep Arzu Yegin, Ferda Can, Lale Aydın Kaynar, Sanem Gökçen, Rezzan Eren Sadioğlu, Zübeyde Nur Özkurt and Özlem Karacaoğlu
134 Expression of serum BMP6 and hepcidin in cancer-related anemia
Zhen Cheng, Min Yan, Ye Lu and Xiang-Tao Pan
139 The association between antinuclear antibody and response to rituximab treatment in adult patients with primary immune thrombocytopenia
Yan-ming Wang, Ya-fei Yu, Yu Liu, Shuang Liu, Ming Hou and Xin-guang Liu
Case Report
145 Congenital fibrinogen disorder caused by digenic mutations of the FGA and FGB genes
Xiong Wang, Ning Tang, Na Shen, Yanjun Lu and Dengju Li
Articles
149 Economic burden of hemophilia A and B: a case in Iran
Khosro Keshavarz, Mohammadreza Bordbar, Zeinab Hashemipoor, Farideh Sadat Jalali and Ramin Ravangard
156 Up to half of patients diagnosed with chronic lymphocytic leukemia in México may not require treatment
Antonio Cruz-Mora, Iván Murrieta-Alvarez, Juan Carlos Olivares-Gazca, Andrés León-Peña, Yahveth Cantero-Fortiz, Yarely Itzayana García-Navarrete, Luisa Fernanda Sánchez-Valledor, Dina Khalaf, Guillermo José Ruiz-Delgado and Guillermo José Ruiz-Argüelles
160 LncRNA SNHG4 regulates miR-10a/PTEN to inhibit the proliferation of acute myeloid leukemia cells
Zhongtao Yuan and Wei Wang
Case Report
165 Disappearance of monosomy 7 in a patient with aplastic anemia after eltrombopag treatment
Yusuke Uchibori, Akira Hangaishi, Yoshimasa Kamoda, Masako Hirao, Hiromitsu Iizuka, Michiko Kida and Kensuke Usuki
Articles
168 Identification of potential miRNA–mRNA interaction network in bone marrow T cells of acquired aplastic anemia
Shuanglong Lu, Anil Kumar Yadav and Xiaohong Qiao
176 Cytogenetic abnormalities in patients with newly diagnosed multiple myeloma as a secondary primary malignancy: a retrospective study
Yiting Wang, Yong Wu, Zhenshu Xu, Huarong Zhou, Yuanzhong Chen and Rong Zhan
181 Impact of anemia on the outcomes of chronic phase chronic myeloid leukemia in TKI era
Zhenyou Liu, Yuye Shi, Zhiling Yan, Zhengmei He, Banghe Ding, Shandong Tao, Yunjie Li, Liang Yu and Chunling Wang
186 Increased circulating basic fibroblast growth factor levels in acute myeloid leukemia: a meta-analysis
Ming-Zhu Song, Yan-Mei Mao, Jun Wu, Hai-Feng Pan and Qian-Ling Ye
194 Fish consumption and risk of non-Hodgkin lymphoma: A meta-analysis of observational studies
Li Yang, Wen-yu Shi, Xiao-hong Xu, Xin-feng Wang, Lu Zhou and De-pei Wu
203 A multicentre retrospective study of primary breast diffuse large B-cell and high-grade B-cell lymphoma treatment strategies and survival
Tingting Zhang, Hongguo Zhao, Zhongguang Cui, Haicang Xu, Xiaodan Liu, Ying Wu, Ying Li, Shuxiang Sun, Peijun Wang, Yanli Wang and Xue Shi
211 Mutational landscape of patients with acute myeloid leukemia or myelodysplastic syndromes in the context of RUNX1 mutation
Kai Wang, Feng Zhou, Xiaohui Cai, Hongying Chao, Ri Zhang and Suning Chen
219 The prognostic impact of abnormally expressed, long noncoding RNAs in acute myeloid leukemia: a meta-analysis
Jie Shi, Xin Shi and Rong-Qin Dai
229 Association between hospital admissions and healthcare provider communication for individuals with sickle cell disease
Robert M. Cronin, Manshu Yang, Jane S. Hankins, Jeannie Byrd, Brandi M. Pernell, Adetola Kassim, Patricia Adams-Graves, Alexis A. Thompson, Karen Kalinyak, Michael DeBaun and Marsha Treadwell
241 Prognostic significance of Twist, ZEB1 and Slug in peripheral T-cell lymphomas
Pyry M. Uotila, Siria A. Lemma, Kirsi-Maria Haapasaari, Katja Porvari, Sini Skarp, Ylermi Soini, Esa Jantunen, Taina Turpeenniemi-Hujanen and Outi Kuittinen
247 Myeloproliferative neoplasms treated with hydroxyurea, pegylated interferon alpha-2A or ruxolitinib: clinicohematologic responses, quality-of-life changes and safety in the real-world setting
Harinder Gill, Garret M.K. Leung, Rita Yim, Paul Lee, Herbert H. Pang, Ho-Wan Ip, Rock Y.Y. Leung, Jun Li, Gianni Panagiotou, Edmond S.K. Ma and Yok-Lam Kwong
258 The diagnostic and prognostic value of MRI in central nervous system involvement of acute myeloid leukemia: a retrospective cohort of 84 patients
Huafei Shen, Yanchun Zhao, Yuanfei Shi, Jianai Sun, De Zhou, Li Li, Xiujin Ye and Wanzhuo Xie
264 The effect of rat nerve growth factor combined with vitamin B on peripheral neuropathy in multiple myeloma patients
Minchao Yan, Yuan Li, Hui Zeng, Xiaoyan Zhao, Haibing Wu, Wenbin Qian and Xiaojun Guo
270 Expression and clinical significance of phospholipase D1 in de novo acute myeloid leukemia
Ying Lu, Jiasi Zhou, Renzhi Pei, Fenglin Li, Jie Jin and Lei Jiang
Letter to the Editor
276 Comprehensive screening for coexisting heterozygous α0-thalassemia in hemoglobin E trait
Chantana Polprasert, Piroonrut Wongprachar, Amornchai Suksusut, Rung Settapiboon, Supaporn Amornsirivat, Jiratchaya Sophonphan, Noppacharn Uaprasert, Pranee Sucharitchan and Ponlapat Rojnuckarin
280 Vulnerability of sickle cell disease persons to the COVID-19 in sub-Saharan Africa
Serge Tonen-Wolyec, Roland Marini Djang’eing’a, Paul Kambale-Kombi, Charles Kayembe Tshilumba, Laurent Bélec and Salomon Batina-Agasa
Case Report
283 Clinical analysis and literature review of a case with the myelodysplastic syndrome/myeloproliferative neoplasm with ring sideroblasts and thrombocytosis
Bing Long, Hao Shi and Cuixia Zhu
Articles
286 Analysis of rare thalassemia caused by HS-40 regulatory site deletion
Shiqiang Luo, Xingyuan Chen, Qingyan Zhong, Qiuhua Wang, Zehui Xu, Liuqun Qin, Jingren Wang, Dejian Yuan, Tizhen Yan and Ning Tang
292 The cut-offs for kappa/lambda ratio in bone marrow immunohistochemistry for the diagnosis of multiple myeloma
Naree Warnnissorn, Jitsupa Treetipsatit and Wasithep Limvorapitak
299 Identification of latent core genes and pathways associated with myelodysplastic syndromes based on integrated bioinformatics analysis
Yuqian Zhu and Lingyun Wu
309 Association between sickle cell disease and dental caries: a systematic review and meta-analysis
Hui Yue, Xinxin Xu, Qin Liu, Xiaozhi Li, Wei Jiang and Bo Hu
Letter to the Editor
320 Mélange intéressante: COVID-19, autologous transplants and multiple sclerosis
Juan Carlos Olivares Gazca, David Gómez Almaguer, Robert Peter Gale and Guillermo José Ruiz Argüelles
Case Report
321 A novel EPB41 p.Trp704* mutation in a Korean patient with hereditary elliptocytosis: a case report
Soyoung Shin, Kyung-Ah Hwang, Kyuhyun Paik and Joonhong Park
Articles
327 Cost burden of breakthrough hemolysis in patients with paroxysmal nocturnal hemoglobinuria receiving ravulizumab versus eculizumab
Ioannis Tomazos, J. Rafael Sierra, Karissa M. Johnston, Antoinette Cheung, Robert A. Brodsky and Ilene C. Weitz
Case Report
335 IgG4 plasma cell myeloma without clinical evidence of IgG4-related disease: a report of two cases
Deonne Thaddeus V. Gauiran, Krista M. Marcon, Mari L. DeMarco, Angela W. S. Fung, Grace van der Gugten, Andre Mattman, Mollie N. Carruthers, Kevin W. Song and Luke Y. C. Chen
Articles
341 Eltrombopag, oral immunosuppressant and androgen combination therapy in twelve patients with refractory severe aplastic anemia
Qingyan Gao, Li Zhang, Xin Zhao, Yangmin Zhu, Guangxin Peng, Yang Li, Yuan Li, Jianping Li, Lin Song, Lei Ye, Huihui Fan, Kang Zhou, Wenrui Yang, Yang Yang, Liping Jing and Fengkui Zhang
348 Small PNH clones detected by fluorescent aerolysin predict a faster response to immunosuppressive therapy in patients with severe aplastic anaemia
Xiang Ren, Xingxin Li, Jiali Huo, Yahong You, Jinbo Huang, Yingqi Shao, Meili Ge, Zhendong Huang, Jing Zhang, Min Wang, Peng Jin, Neng Nie and Yizhou Zheng
356 Haploidentical stem cell transplantation vs matched unrelated donor transplantation in adults with hematologic malignancies: a systematic review and meta-analysis
Liyuan Ma, Xue Han, Suyu Jiang, Qingqi Meng, Liubo Zhang and Hongyu Bao
366 Real-world analysis of treatment patterns and clinical outcomes in patients with newly diagnosed chronic lymphocytic leukemia from seven Latin American countries
Carlos Chiattone, David Gomez-Almaguer, Carolina Pavlovsky, Elena J. Tuna-Aguilar, Ana L. Basquiera, Luis Palmer, Danielle Leao Cordeiro de Farias, Sergio Schusterschitz da Silva Araujo, Kenny Mauricio Galvez-Cardenas, Alvaro Gomez Diaz, Jennifer H. Lin, Yen-wen Chen, Gerardo Machnicki, Michelle Mahler, Lori Parisi and Paula Barreyro
372 Diaphragm ultrasonography in adults with sickle cell anemia: evaluation of morphological and functional aspects
Rachel Zeitoune, Roberto Mogami, Ana Celia Baptista Koifman, Agnaldo Jose Lopes, Andrea Ribeiro Soares, Rosangela Aparecida Gomes Martins and Maria Christina Paixão Maioli
383 Hematologic predictors of mortality in hospitalized patients with COVID-19: a comparative study
Seied Asadollah Mousavi, Soroush Rad, Tahereh Rostami, Mohammadreza Rostami, Seyed Ali Mousavi, Seied Amirhosein Mirhoseini and Azadeh Kiumarsi
389 Malignancy-associated hemophagocytic lymphohistiocytosis in children: a 10-year experience of a single pediatric hematology center
Zhizhuo Huang, Yueping Jia, Yingxi Zuo, Jun Wu, Aidong Lu and Leping Zhang
Case Report
400 A novel β-thalassemia variant at HBB:c.14delC (Codon 4, -C) identified via next-generation sequencing
Junkun Chen, Shaobin Lin, Jinghui Gan, Xiaoqin Xin and Jungao Huang
Articles
405 Diagnostic, prognostic and predictive values of miR-100 and miR-210 in pediatric acute lymphoblastic Leukemia
Naglaa M. Hassan, Lobna A. Refaat, Ghada N. Ismail, Mona Abdellateif, Sayed A. Fadel and Rania S. AbdelAziz
414 The efficacy and adverse events of venetoclax in combination with hypomethylating agents treatment for patients with acute myeloid leukemia and myelodysplastic syndrome: a systematic review and meta-analysis
Yuancheng Guo, Bei Liu, Lijuan Deng, Yanhong Qiao and Jinli Jian
424 Blockade of PLD1 potentiates the antitumor effects of bortezomib in multiple myeloma cells by inhibiting the mTOR/NF-κB signal pathway
Yanfang Wang, Fei Dong, Wei Wan, Zhenhao Zhang, Jing Wang, Hua Wang and Xiaoyan Ke
433 Prognostic factors for patients with multiple myeloma admitted to the intensive care unit
Xiangwen Diao, Ruibin Cai, Jieyu Luo, Zhiwei Zheng and Hong Zhan
438 Hereditary spherocytosis overlooked for 7 years in a pediatric patient with β-thalassemia trait and novel compound heterozygous mutations of SPTA1 gene
Min Chen, Yu-Ping Ye, Lin Liao, Xue-Lian Deng, Yu-Ling Qiu and Fa-Quan Lin
446 Clinical characteristics and prognostic study of adult acute myeloid leukemia patients with ASXL1 mutations
Yun Lin, Yaping Wang, Yi Zheng, Zechuan Wang, Yanni Wang and Shaoyuan Wang
457 The role of cystatin C as a proteasome inhibitor in multiple myeloma
Yijing Jiang, Jie Zhang, Chenlu Zhang, Lemin Hong, Yuwen Jiang, Ling Lu, Hongming Huang and Dan Guo
464 The predictive value of pre-treatment paroxysmal nocturnal hemoglobinuria clone on response to immunosuppressive therapy in patients with aplastic anemia: a meta-analysis
Biao Wang, Bai He, Yuan-dong Zhu and Wei Wu
Case Report
473 Spontaneous recovery in a patient with acquired thrombotic thrombocytopenic purpura (TTP): observation of a ‘subclinical’ TTP state
Sabrina Browning, Burak Bahar, Alfred Ian Lee and Elan Gorshein
Article
478 Tacrolimus is effective in relapsed/refractory autoimmune cytopenias: results of a single-center retrospective study
Yali Du, Chen Yang, Miao Chen, Jing Ruan, Yuzhou Huang, Fangfei Chen and Bing Han
Case Report
484 Normal activated partial thromboplastin time in Chinese patients with mild hemophilia B
Xiong Wang, Ning Tang, Na Shen, Yaowu Zhu, Yanjun Lu and Linna Gao
Articles
489 Efficacy and safety of four-factor prothrombin complex concentrate fixed, weight-based dosing for reversal of warfarin anticoagulation
Kaitlin Endres, Rosanne St. Bernard, Ian Chin-Yee, Cyrus Hsia and Alejandro Lazo-Langner
494 Prognostic effect of RUNX1 mutations in myelodysplastic syndromes: a meta-analysis
Wei He, Caifang Zhao and Huixian Hu
Case Report
502 A novel homozygous missense mutation (Met527Ile) in a consanguineous marriage family with inherited factor XII deficiency
Meina Liu, Huanhuan Wang, Miaomiao Lin, Yanhui Jin, Lihong Yang and Mingshan Wang
Article
507 Hyperleukocytosis predicts inferior clinical outcome in pediatric acute myeloid leukemia
Lu-Hong Xu, Jing-Wen Wang, Yin Wang and Feng-Ying Yang