Clinical significance of prognostic nutritional index in myelodysplastic syndrome

ABSTRACT

Background

Prognostic nutritional index has been found to be related to the clinical outcomes of patients with cancer. However, its role in myelodysplastic syndromes (MDS) patients is unclear. We aimed to assess the value of nutritional status in predicting the prognosis of MDS patients.

Methods

Totally 121 MDS patients were analyzed retrospectively. The prognostic nutritional index (PNI) was used to assess nutritional status of the patients. The bio-informatics tool X-tile was used to define the threshold, and accordingly patients were divided into PNI^low and PNI^high groups, the characteristics were compared between two groups.

Results

The PNI^high was associated with better OS (Overall Survival) than PNI^low in MDS patients (Median OS, 28.03 months versus 19.63 months, P = 0.0205). But there were no statistical differences in PFS (Progression-Free-Survival) between the two groups (P = 0.9373). The univariable and multivariable COX proportional hazard analysis adjusted for age, gender, platelet count, HB level and IPSS-R scores, and the results showed that PNI is a useful index in the evaluation of the OS of MDS (HR 0.588, 95%CI 0.374–0.926, P = 0.024).

Conclusion

PNI would be a simple and immediately available tool for predicting the prognosis of MDS.

KEYWORDS:

• Myelodysplastic syndromes (MDS)
• prognostic nutritional index (PNI)
• prognosis
• nutritional status

Disclosure statement

No potential conflict of interest was reported by the author(s).

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was waived because of the retrospective design of the data collection.

Additional information

Funding

This study was funded by the Science and Technology Fund of Huaian City [grant number HAB202020] and the Commission of Health of Jiangsu Province [grant number 2019082].