Large endolymphatic duct and sac syndrome (LEDS) in monozygotic mirror twins

An Boudewyns Departments of Otorhinolaryngology, Head and Neck Surgery, Antwerp University Hospital, University of Antwerp, BelgiumCorrespondence[email protected]

Frank Declau Departments of Otorhinolaryngology, Head and Neck Surgery, Antwerp University Hospital, University of Antwerp, Belgium

Jenneke Van Den Ende Medical Genetics, Antwerp University Hospital, University of Antwerp, Belgium

Anremiek Snoeckx Radiology, Antwerp University Hospital, University of Antwerp, Belgium

Paul M. Parizel Radiology, Antwerp University Hospital, University of Antwerp, Belgium

Paul H. Van De Heyning Departments of Otorhinolaryngology, Head and Neck Surgery, Antwerp University Hospital, University of Antwerp, Belgium

Abstract

We present monozygotic twin sisters with a non-syndromic enlargement of the endolymphatic duct and sac. The diagnosis was confirmed with magnetic resonance imaging (MRI) and DNA typing. The twins were concordant for the inner ear malformation and subsequent confirmation of the hearing loss in each twin demonstrated a mirror image phenotype.

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Large endolymphatic duct and sac syndrome (LEDS) in monozygotic mirror twins

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Large endolymphatic duct and sac syndrome (LEDS) in monozygotic mirror twins

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