Heterocycles derived from dimethyldithioimidocarbonates of thiadiazole and thiazole

Abstract

A set of imidazolidine, benzimidazole, benzothiazole and benzoxazole derivatives of 1,3,4-thiadiazoles and thiazoles were prepared from corresponding dimethyldithioimidocarbonates by the reaction with various binucleophiles. The structures of the compounds were elucidated and they were screened for antitubercular activity against Mycobacterium tuberculosis H₃₇Rv using the BACTEC 460 radiometric system and antibacterial activity against E. coli and B. cirrhosis, antifungal activity against A. niger and P. worthmanni.

Keywords:

• Dimethyldithioimidocarbonate
• Imidazolidines
• Antitubercular activity
• Antimicrobial activity

Acknowledgements

Authors are thankful to Tuberculosis Antimicrobial Acquisition and Coordinating Facility (TAACF) for anti-tuberculosis evaluations.