Oxidation of thiols with methyltriphenylphosphonium dichromate (MTPPD) in dichloromethane at room temperature

Abdol R. Hajipour Department of Pharmacology, University of Wisconsin, Medical School, 1300 University Avenue, Madison, WI, 53706-1532, USA; Pharmaceutical Research Laboratory, College of Chemistry, Isfahan University of Technology, Isfahan, 84156, IR, IranCorrespondence[email protected]

Somayeh Safai Department of Pharmacology, University of Wisconsin, Medical School, 1300 University Avenue, Madison, WI, 53706-1532, USA

Arnold E. Ruoho Department of Pharmacology, University of Wisconsin, Medical School, 1300 University Avenue, Madison, WI, 53706-1532, USA

Abstract

A chemoselective, straight-forward and rapid method for oxidation coupling of thiols to the corresponding disulfides using methyltriphenylphosphonium dichromate (MTPPD) in dichloromethane at room temperature. The reaction has been carried out in excellent yield and short reaction time.

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Acknowledgements

We gratefully acknowledge the funding support received for this project from the Isfahan University of Technology (IUT), I.R. Iran (A. R. H.) and Grants GM 033138, MH 065503, NS 033650 (A. E. R.) from the National Institutes of Health, USA. Further financial support from Center of Excellency in Chemistry Research (IUT) is gratefully acknowledged.

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Oxidation of thiols with methyltriphenylphosphonium dichromate (MTPPD) in dichloromethane at room temperature

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Oxidation of thiols with methyltriphenylphosphonium dichromate (MTPPD) in dichloromethane at room temperature

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