Microwave-assisted solid-phase chemistry for rapid efficient generation and trapping of sulfenic acids

Abstract

An easy two step procedure starting from commercially available REM resin allowed the preparation of suitable solid-supported precursors of sulfenic acids. Their microwave-assisted generation and trapping resulted superior to the conventional solution-phase procedure and thermal heating in terms of simplicity, eco-compatibility, and final yields.

Keywords:

• Green chemistry
• Microwaves
• Solid-phase
• Sulfenic acids
• Sulfoxides

Acknowledgements

Work carried out in the framework of the National Projects ‘Stereoselezione in sintesi organica. Metodologie ed applicazioni’ and ‘Cicloaddizioni a basso impatto ambientale per la sintesi di sostanze di interesse biologico’ supported by the Ministero dell'Istruzione, dell'Universita‘e della Ricerca (MIUR), and by the Universities of Florence and Messina. The ‘Ente Cassa di Risparmio di Firenze’ is also acknowledged for acquisition of a 400 MHz NMR.