Electrogenerated base-promoted synthesis and antimicrobial activity of 2-(1,3-dithian-2-ylidene)-2-arylacetonitrile and 2-(1,3-dithiolan-2-ylidene)-2-arylacetonitrile

Abstract

The new preparation of 2-(1,3-dithian-2-ylidene)-2-arylacetonitrile and 2-(1,3-dithiol-2-ylidene)-2-arylacetonitrile is described. The electrogenerated cyanomethyl base/anion obtained from the electroreduction of acetonitrile promotes reactions between arylacetonitrile, carbon disulfide and 1-bromo-3-chloropropane or 1,2-dibromoethane. Obtained products have been identified according to their spectroscopic data (IR and ¹H NMR and ¹³C NMR) and elemental analysis. The possible antibacterial activities of some of these compounds were investigated. Promising results were found against few types of bacteria.

GRAPHICAL ABSTRACT

Keywords:

• 2-(1,3-dithian-2-ylidene)-2-arylacetonitrile
• 2-(1,3-dithiol-2-ylidene)-2-arylacetonitrile
• anion EGBs
• carbone disulfur
• antimicrobial activity

Acknowledgements

The authors gratefully acknowledge the Tunisian “Ministère de l'Enseignement Supérieur, de la Recherche et la Technologie” for Financial support (Lab CH-02).

Disclosure statement

No potential conflict of interest was reported by the authors.