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Research Article

Regio- and stereo-selective ring expansion of keto-aziridines to the corresponding thiomorpholines

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Pages 510-518 | Received 31 Jan 2021, Accepted 01 Apr 2021, Published online: 22 Apr 2021
 

Abstract

In this research, an efficient process for the synthesis of the some novel 3-thiomorpholines from a regio- and stereo-selective reaction of ketoaziridines with 2-mercaptoacetic acid in the presence of dicyclohexyl carbodiimide is reported. A plausible mechanism has been proposed.

GRAPHICAL ABSTRACT

Acknowledgements

We are thankful to the Shahrekord University for the support of this work.

Disclosure statement

No potential conflict of interest was reported by the author(s).

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