Three-component reaction between ethyl carbazate and aroyl chlorides with ammonium thiocyanate under solvent-free conditions: synthesis of 1,2,4-triazole-3-thione derivatives

Abstract

We reported a three-component, simple, one-pot and novel method for the synthesis of 1,2,4-triazole-3-thione derivatives from the condensation of ammonium thiocyanate and aroyl chlorides with ethyl carbazate under solvent-free conditions. The structures of compounds were deduced from elemental analysis and their IR, ¹H NMR, ¹³C NMR spectra. This new protocol offers advantages such as mild reaction conditions, short reaction time, easy work-up, high yields and does not involve any hazardous solvent. Therefore, this procedure could be classified as green chemistry.

GRAPHICAL ABSTRACT

KEYWORDS:

• Ethyl carbazate
• aroyl chlorides
• ammonium thiocyanate
• triazole-3-thiones
• solvent-free

Acknowledgements

We gratefully acknowledge financial support from the Research Council of Islamic Azad University of Kerman and The Islamic Azad University of Zahedan of Iran.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

We gratefully acknowledge financial support from the Research Council of Islamic Azad University of Kerman and The Islamic Azad University of Zahedan of Iran.