Copper-Catalyzed direct thioetherification of Alkyl Halides with S-Alkyl Butanethioate as Thiol transfer reagent

Abstract

A new and convenient copper-catalyzed synthesis of alkyl sulfides has been accomplished using S-alkyl butanethioate as a thiol source. This catalytic protocol displayed a good functional groups tolerance and high efficiency. Both secondary and primary alkyl iodides can be used in this procedure. In addition, this method features operational simplicity and a wide substrate range, providing a complementary method for alkyl sulfide synthesis without requiring toxic thiols and noble metals.

GRAPHICAL ABSTRACT

KEYWORDS:

• Cu-catalyzed
• thioetherification
• alkyl iodide
• radical
• thioether

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

The financial support through a research grant 22101005 from National Natural Science Foundation of China, 1908085MC71 from Anhui Provincial Natural Science Foundation Returned Overseas Students Innovation and Entrepreneurship Project of Hefei, Leading talent project of Anhui Province - Young Wanjiang scholars.