Deep eutectic solvents with ultrasonic energy as an environmentally benign and green approach for the synthesis of bisthioglycolic acid derivatives

Abstract

The present methodology explored the effectiveness and versatility of deep eutectic solvent with ultrasonic energy as an eco-friendly protocol for the synthesis of bisthioglycolic acid derivatives. Bisthioglycolic moiety holds its role as a potent scaffold in sulfur-containing drugs. The presented strategy offers significant advantages such as green catalyst as well as solvent, excellent yield, short reaction time, and simple reaction workup. This methodology shows a wide range of substrate scope that contain both electron-donating as well as electron-withdrawing groups.

GRAPHICAL ABSTRACT

KEYWORDS:

• Ultrasonic energy
• green chemistry
• bisthioglycolic acid
• deep eutectic solvent
• carbon–sulfur bond formation

Acknowledgment

RK & JKR are thankful to SERB New Delhi for the research grant (TAR/2022/00520). PS gratefully acknowledges the National Research Foundation (SA) for a Competitive grant for rated researchers (Grant Number: SRUG2204092857). The authors are also thankful to the IKGPTU, Kapurthala for providing all the necessary research facilities.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This work was supported by National Research Foundation (SA): [Grant Number SRUG2204092857]; Science and Engineering Research Board: [Grant Number TAR/2022/00520].