Magmaris resorbable magnesium scaffold for the treatment of coronary heart disease: overview of its safety and efficacy

ABSTRACT

Introduction: Bioresorbable scaffold technology provides transient vessel support with drug-delivery capability without the long-term limitations of the permanent metallic drug-eluting stents (DES). The technology has the potential to overcome many of the safety concerns associated with metallic DES, such as hypersensitivity reactions, late stent thrombosis and progression of atherosclerosis within the stented segment (i.e. neoatherosclerosis).

Areas covered: The sirolimus-eluting resorbable magnesium scaffold Magmaris is the only metallic CE-marked resorbable scaffold currently available. This magnesium scaffold is designed for providing a short-term lumen support (up to 3 months) before being completely bioresorbed, eliminating the permanent caging typical of the metallic DES. This review will focus on the device development and characteristics, currently available clinical efficacy and safety data, and potential future perspectives.

Expert opinion: The first clinical studies testing this device in a small number of patients have shown promising results with good clinical and safety outcomes up to 3 years’ clinical follow-up, supporting the use of Magmaris in simple coronary artery disease.

KEYWORDS:

• Magmaris
• resorbable scaffold
• coronary artery disease
• percutaneous coronary intervention
• magnesium
• bioresorption

Declaration of interest

J Bennett has received research grants and consultancy fees from Biotronik AG, research grants and speaking fees from Abbott Vascular and consultancy fees from Boston Scientific. Q De Hemptinne has received research grants and speaker honoraria from Biotronik AG, and research grants from Abbott Vascular. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

Reviewer disclosures

Peer reviewers on this manuscript have no relevant financial or other relationships to disclose.

Additional information

Funding

This paper was not funded.