Diet and prevention of type 2 diabetes mellitus: beyond weight loss and exercise

ABSTRACT

Introduction: Insulin resistance (IR) and pancreatic beta-cell dysfunction are core pathophysiologic features of type 2 diabetes mellitus (T2DM). Select lifestyle and pharmacologic interventions, including weight loss, physical activity, a Mediterranean diet intervention, and hypoglycemic agents, have been shown to prevent or delay T2DM. However, dietary factors other than weight loss may also impact risk, mainly through effects to enhance insulin sensitivity, although some may also directly or indirectly impact pancreatic beta-cell function.

Areas covered: A literature review of observational studies and randomized controlled trials (RCTs) was conducted, and the research indicates dietary factors showing promise for reducing T2DM risk include higher intakes of cereal fibers, unsaturated fatty acids, magnesium, and polyphenols (e.g. anthocyanins), while reducing dietary glycemic load, added sugars, and high-sugar beverages.

Expert commentary: While these dietary factors are mainly supported by evidence from observational studies and RCTs of surrogate markers for T2DM, they are consistent with current recommendations to emphasize consumption of whole grains, nuts, seeds, legumes, seafood, fruits, and vegetables, while limiting intakes of saturated fatty acids, refined carbohydrates, and processed meats. Additional dietary intervention RCTs are needed to assess the efficacy of these promising dietary interventions for delaying or preventing the onset of T2DM.

KEYWORDS:

• Diabetes
• prediabetes
• dietary guidance
• diet pattern
• insulin resistance
• insulin sensitivity
• glycemia
• macronutrient replacement
• fiber
• bioactive

Declaration of interest

The authors have accepted research funding and/or consulting fees from commodity boards (National Dairy Council, Hass Avocado Board, American Egg Board and National Dairy Council), food companies (ACH Foods, Kellogg, General Mills) and pharmaceutical companies (AstraZeneca, Novo Nordisk) relevant to the topic reviewed. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

Reviewer disclosures

Peer reviewers on this manuscript have no relevant financial or other relationships to disclose.

Additional information

Funding

This paper was not funded.