Indomethacin for prevention of ectopic ossification in cementless hip arthroplasties

A prospective 1-year study of 100 cases

Christian Wurnig Vienna University, Department of Orthopedics, Allgemeines Krankenhaus, Währinger Gürtel 18,A-1090, Vienna, Austria, Tel +43-222 40400 4078., Fax -222 40400 4077

Richard Eyb Vienna University, Department of Orthopedics, Allgemeines Krankenhaus, Währinger Gürtel 18,A-1090, Vienna, Austria, Tel +43-222 40400 4078., Fax -222 40400 4077

Vinzenz Auersperg Vienna University, Department of Orthopedics, Allgemeines Krankenhaus, Währinger Gürtel 18,A-1090, Vienna, Austria, Tel +43-222 40400 4078., Fax -222 40400 4077

Abstract

In a prospective series of 100 patients we investigated the effect of indomethacin for 6 weeks in the prophylaxis of ectopic bone formation in hip replacements with cementless fixation. Indomethacin prophylaxis reduced (P < 0.0001) ectopic bone formation compared to a retrospective control group of equal size. Side-effects occurred in one-fifth of the patients, but most of these could continue the medication for at least 4 weeks.

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Indomethacin for prevention of ectopic ossification in cementless hip arthroplasties

A prospective 1-year study of 100 cases

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Indomethacin for prevention of ectopic ossification in cementless hip arthroplasties

A prospective 1-year study of 100 cases

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