Anti-breast carcinoma effects of green synthesized tin nanoparticles from Calendula officinalis leaf aqueous extract inhibits MCF7, Hs 319.T, and MCF10 cells proliferation

Abstract

In this study, tin nanoparticles were green synthesized using the aqueous extract of Calendula officinalis. Different techniques such as FE-SEM, XRD, FT-IR, and EDS analysis were used to characterize SnNPs@ C. officinalis. A 21.87 nm was obtained for the crystal size of the tin nanoparticles using XRD analysis. The FE-SEM images show a spherical morphology for SnNPs@ C. officinalis with a range size of 21.63–64.07 for the synthetic nanoparticles. The anti-breast cancer effects of biologically synthesized SnNPs@ C. officinalis against breast cancer cell lines were assessed. The anti-breast cancer properties of the SnNPs@ C. officinalis could significantly remove the MCF7, Hs 319.T, and MCF10 cancer cell lines in a time and concentration-dependent manner by MTT assay. The antioxidant activity of SnNPs@ C. officinalis was determined by the DPPH method. The SnNPs@ C. officinalis showed the highest antioxidant activity according to the IC₅₀ value. It seems the anti-human breast cancer effect of recent nanoparticles is due to their antioxidant effects.

Keywords:

• Tin
• Calendula officinalis extract
• green synthesis
• breast cancer

Data availability statement

Data available on request from the authors.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Figure 5. EDS analysis of SnNPs@ C. officinalis.