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Abstract
In this study, copper nanoparticles were synthesised according to green chemistry rules using the aqueous extract of Alhagi maurorum. The green-synthesised CuNPs were characterised using different techniques such as EDX, FE-SEM, XRD and FT-IR. The FE-SEM results confirm spherical morphology for the nanoparticles with a size of 42.68–68.87 nm. In vivo, the Mycoplasma pneumonia injection was applied for inducing pneumonia in the BALB/c mice, also the treatment was with CuNPs. The serum parameters such as inflammatory mediators (IL-6, TNF-α, IL-8, TGF and IL-1), total cell counts, and total protein content levels were evaluated. CuNPs regulated the levels of the inflammatory mediators in the infected mice. The cellular arrangements at the histopathological images were ameliorated with the administration of CuNPs. At the antioxidant test, the CuNPs and BHT removed 50% of free radicals at the concentrations of 181 and 110 µg/ml. In conclusion, the results revealed the ameliorative property of CuNPs green-formulated by A. maurorum aqueous extract on M. pneumoniae infected pneumonia mice model.
Disclosure Statement
No potential conflict of interest was reported by the author(s).
Data availability statement
Data is available on request from the authors.
Additional information
Notes on contributors
Tian Liyuan
Tian Liyuan was appointed as the director of area A of the Respiratory of Hebei Children's Hospital, has completed his Master's in the University of Milano Bicocca in Italy and Hebei Medical University. He is the leader of Futang Medical Development Center of Beijing Children's Hospital Group and the respiratory professional discipline leader of Hebei Children's Hospital, and serves as the vice president and member of many medical societies in Hebei Province. He has Published a number of SCI papers, domestic core journal papers, the paper “gestational age, weight and hypoxia on neonatal fibrinolytic activity” won the third prize of the Provincial Department of Science and Technology.
Zhang Lijun
Zhang Lijun is an attending physician working in the Hebei Children's Hospital. Her research mainly focuses on the diagnosis and treatment of severe respiratory diseases in children.
Hou Wei
Hou Wei is an attending physician working in the Hebei Children's Hospital.Good at the diagnosis and treatment of severe respiratory diseases in children, the main research direction of children viral pneumonia and fungal pneumonia.
Jia Meixuan
Jia Meixuan has completed his Master's in Shanxi Medical University and is an attending docter, currently working in the Hebei Provincial Children's Hospital. His research interests include Mycoplasma pneumoniae pneumonia and respiratory tract related allergic diseases.
Zhang Man
Zhang Man is a senior attending physician in area A of the Respiratory Department of Hebei Children's Hospital and has been engaged in pediatric clinical work for 17 years. She has accumulated rich experience in the diagnosis and treatment of pediatric diseases, and is often invited to consult in other departments. He is especially good at the diagnosis and treatment of children's recurrent cough, pneumonia, bronchiolitis, bronchial asthma, cough variant asthma, interstitial lung diseases and respiratory diseases. And she has participated in a number of provincial projects and a number of GCP projects.
Yan Zhihui
Yan Zhihui has completed her Master's degree in internal medicine from the Research Institute of Hebei Medical University, and she is currently working in the Respiratory Department of Hebei Children's Hospital. Her main research directions are respiratory syncytial virus infection and children's bronchial asthma.
Li Qingtao
Li Qingtao, Deputy Chief Physician, Hebei Children's Hospital, Member of Hebei Pediatric Society, Member of Expert Committee of China Children's Asthma Action Plan, Member of Hebei Provincial Association of Integrated Traditional Chinese and Western Medicine Pediatric Cardiovascular Society. Focus on the diagnosis and treatment of common diseases, frequently-occurring diseases and critical illnesses of children's respiratory system, and skilled in the technology of fiberoptic bronchoscopy.
Qian Xiaona
Qian Xiaona, a master's degree and resident, graduated from Hebei Medical University and is good at frequent respiratory diseases and common diseases in children.
Wang Qian
Wang Qian, master of clinical medicine, resident doctor of Hebei Province Children's Hospital, focus on the diagnosis and treatment of common diseases and frequently-occurring diseases of children's respiratory system.
Tian Jiangling
Tian Jiangling is a resident at Hebei Children's Hospital and has completed her Master's in Hebei Medical University and is good at the diagnosis and treatment of serious respiratory diseases in children.
You Dianping
You Dianping was appointed as the secretary of the party committee of Hebei Children's Hospital, and was awarded the title of outstanding contribution worker of the National Health Commission to improve medical service, winner of Hebei Provincial Government quality Award (individual Award) and Hebei Province advanced individual fighting against COVID-19 epidemic situation. He served as the president or vice president of many societies, associations, councils and medical federations in Hebei Province, mainly engaged in social medicine and health management. He has published many articles and won the second prize of science and technology in Hebei Province.
Wang Yakun
Wang Yakun is a deputy chief physician in the Children's Hospital of Hebei Provence, in the Department of Respiratory. Her area of interest includes the diagnosis and treatment of respiratory diseases in children. She also specializes in fibroptic bronchoscopy.