Orbital inflammatory disease management

ABSTRACT

Introduction: Orbital inflammatory disease (OID) represents a spectrum of conditions that can be placed into two groups, specific orbital inflammatory disease (SOIS) and nonspecific orbital inflammatory disease (NSOIS). This manuscript aims to systematically review the therapies for the different types of OID.

Areas covered: The therapy for OID has evolved significantly with the advent of biologic medications, although certain mainstays are still widely used. The authors conducted a review of literature published in the last 20 years with the use of PubMed. This article is organized according to disease syndrome. Specific diseases and their associated treatments are addressed.

Expert commentary: Although corticosteroids are still the mainstay of treatment in most OID, a focus on disease specificity combined with increasing understanding of inflammatory pathways has allowed utilization of inflammatory modulatory medications. Investigating these therapeutics in prospective trials will likely be the vital link to improving patient care in orbital inflammatory disease.

KEYWORDS:

• Orbital inflammation
• orbital inflammatory disease
• orbital inflammatory disease treatment
• orbital inflammation treatment review
• orbital inflammatory disease treatment review
• granulomatosis with polyangiitis orbit
• sclerosing orbital inflammation
• idiopathic orbital inflammation treatment
• orbital myositis
• Castleman’s disease orbit treatment

Declaration of interest

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

Additional information

Funding

No funding was received.