The role of cell-free DNA in predicting colorectal cancer prognosis

ABSTRACT

Introduction: Colorectal cancer is a cancer of the digestive system with poor prognosis. Cell-free DNA has received much attention with its unique predominance, especially in colorectal cancer.

Areas covered: This study has summarized recent advancements and challenges regarding cell-free DNA in predicting CRC prognosis. Furthermore, the authors make predictions on the potential developments concerning cell-free DNA in future prognosis prediction techniques.

Expert commentary: Cell-free DNA has the value of predicting CRC prognosis as an important biomarke. Further clinical trials should be performed to promote translating cell-free DNA into clinical applications.

KEYWORDS:

• Colorectal cancer
• cell-free DNA
• prognosis
• DNA mutation
• DNA methylation

Declaration of interest

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

Additional information

Funding

This paper was supported by grants from the Key State Laboratory of Cancer Biology: CBSKL2014Z13, and a grant from the National Clinical Research Center for Digestive Disease: 2015BAI13B07.