http://orcid.org/0000-0002-3684-9271
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ABSTRACT
Background: Sorafenib is the standard of care, first line treatment for advanced HCC. This study aims to evaluate real-life efficacy and safety of sorafenib in Egyptian patients with Hepatocellular carcinoma (HCC).
Methods: This retrospective cohort study was conducted in the medical oncology department at Maadi Armed Forces Medical Compound. Patients with advanced HCC who received sorafenib between January and December 2015 were included (130 patients).
Results: The median overall survival of patients with HCC treated with sorafenib was 5 months (CI: 4.166–5.834), and progression free survival was 4 months (CI: 3.479–4.521). Disease control rate was 45.44% with 2 patients experiencing complete remission (1.2%). The adverse events rate was 76.1% for toxicities of all grades; with hand and foot syndrome being the most common (32.3% of any grade) and liver dysfunction the most common grade III toxicity (13.8%). Treatment was stopped for radiological progression based on modified RECIST criteria in 47 patients (36.3%), 18 patients stopped the treatment for intolerable toxicity. At the end of treatment upon radiological progression, 51 patients (39.2%) were still classified as Child A class of cirrhosis.
Conclusion: Sorafenib use should be limited to patients with Child A, PS 0–1, and low disease burden.
Author contributions
Yousery Nada, Noha Rashad, Omar Abdel Rahman were involved in the design of the study and writing the manuscript. Mai Eissa,Aya Ghonaim, Kyrillus Farag, Islam Saadawi, Ahmed Sheha, Mahmoud El gewaity contributed to the data collection and data entry.
Declaration of interest
The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties. Peer reviewers on this manuscript have no relevant financial or other relationships to disclose.