Assessment of functional status by the Duke Activity Status Index in stable bronchiectasis

ABSTRACT

Introduction

Bronchiectasis is a growing global health problem.

Objective and Methods

To evaluate the functional status of stable bronchiectasis patients recruited from a terciary hospital in Fortaleza, Brazil.The patients were submitted to spirometry, six minute walking test (6MWT), step test (6MST),   measurement of fibrinogen,E-FACED scores(incorporates FEV1 ,age,colonisation by Pseudomonas,radiological extension, dyspnoea and exarcebation) and Duke Activity Status Index(DASI) test.Each item of DASI scored proportionally to the metabolic equivalentes(METs). The sum of DASI scores was applied for an estimation of oxygen consumption(VO2).

Results

The sample comprised 101 patients.Patients with post-tuberculosis bronchiectsis had the lowest level of functional parameters than those with others etiologies[DASI(19.9 ±10.9 vs 31.2±14.4 p<0.001); VO2 (18.1 ± 4.7 vs 23.1 ± 6.1 p< 0.001 respectively)]. DASI scores and estimated VO2 correlated with E-FACED(r= -0.44 p=0.001; and  r= -0.44 p=0.001 respectively) and 6MST r= 0.37 p<0.001 and r=0.40 p<0.001 respectively).

Conclusion

After multivariate analysis , bronchiectasis post-TB , E-FACED and 6MWT explained the impact on performance in bronchiectasis patients.

KEYWORDS:

• Bronchiectasis
• Duke Activity Status Index (DASI)
• oxygen consumption
• FACED
• 6 min walk test
• 6 min step test

Author contributions

E.Pereira: Writing – original draft, Writing - review & editing, formal analysis. I. Lomonaco: Conceptualization, Methodology, supervision, A. Souza Araújo: original draft, formal analysis. Mara Rúbia F de Figueiredo: Methodology, supervision, M.A. Holanda: Writing - review & editing. All authors agree to take responsibility and be accountable for the contents of this article and to share responsibility to resolve any questions raised about the accuracy or integrity of the published work

Declaration of interest

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

Reviewer disclosures

Peer reviewers on this manuscript have no relevant financial or other relationships to disclose.

Additional information

Funding

This paper was funded by CNPq .