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Declaration of interest
TM Polasek and A Rostami-Hodjegan are both employees of Certara. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.
Reviewer disclosures
Peer reviewers on this manuscript have no relevant financial or other relationships to disclose.
Additional information
Funding
This manuscript was not funded but was supported by Certara, the makers of biosimulation tools to aide drug development.