An efficient, catalyst free synthesis of 3-(2′'-benzothiazolyl)-2,3-dihydroquinazolin-4(1H)-ones in aqueous medium

Abstract

An efficient and environmentally benign protocol for the synthesis of 3-(2′-benzothiazolyl)-2,3-dihydroquinazolin-4(1H)-ones has been developed. The synthesis of these pharmacologically important compounds can be achieved by the three component condensation of isatoic/5-chloroisatoic anhydride, aldehyde, and 2-aminobenzothiazole in water: ethanol (1:1, v/v) without the aid of any catalyst.

Keywords:

• multicomponent reaction
• isatoic anhydride
• aldehyde
• 2-aminobenzothiazole

Acknowledgements

SK thanks CSIR New Delhi (India) for the grants of junior and senior research fellowships.