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RESEARCH LETTERS

A convenient, eco-friendly, and efficient method for synthesis of bis(3-indolyl)methanes “on-water”

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Pages 321-327 | Received 21 May 2011, Accepted 09 Aug 2011, Published online: 05 Dec 2011
 

Abstract

A convenient, eco-friendly, and efficient method for synthesis of bis(3-indolyl)methanes by the reaction of indoles with various aromatic aldehydes “on-water” has been developed. The attractive features of this method are that in cases of aldehydes which are easily oxidized to acids, no external catalyst is necessary while in other cases a trace amount (ca. 5 mol%) of commercially available and inexpensive catalyst benzoic acid is sufficient to give good to excellent yield of products.

Acknowledgements

Financial assistance from the UGC-CAS and DST-PURSE programs, Department of Chemistry, Jadavpur University, is gratefully acknowledged. The authors also thank Prof. D. Mal, Department of Chemistry, IIT, Khargarpur, and the DST-FIST program to the Department of Chemistry, Jadavpur University for providing the NMR spectral data. CG is thankful to UGC, New Delhi, for a Research Fellowship.