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RESEARCH LETTERS

Polyethylene glycol mediated facile protocol for N-Cbz protection of amines

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Pages 337-342 | Received 30 May 2011, Accepted 31 Aug 2011, Published online: 31 Jan 2012
 

Abstract

We have reported an efficient and eco-friendly protocol for the protection of various structurally and electronically divergent aryl and aliphatic amines using Cbz-Cl in the presence of polyethylene glycol (PEG)-400 at room temperature. The reaction afforded excellent yields with low as well as high molecular weight PEGs.

Acknowledgements

We gratefully acknowledge the financial support from the Department of Science and Technology (DST), New Delhi.