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Green Chemistry Letters and Reviews Volume 6, 2013 - Issue 3
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RESEARCH LETTERS

Green methodologies in organic synthesis: recent developments in our laboratories

Ebtesam Abdul Aziz Hafez Chemistry Department, Faculty of Science, Cairo University, Giza, Egypt
,
Saleh Mohammed Al-Mousawi Chemistry Department, Faculty of Science, Kuwait University, Safat, Kuwait
,
Moustafa Sherief Moustafa Chemistry Department, Faculty of Science, Kuwait University, Safat, KuwaitCorrespondence[email protected]
,
Kmal Usef Sadek Chemistry Department, Faculty of Science, Minia University, Minia, Egypt
&
Mohamed Hilmy Elnagdi Chemistry Department, Faculty of Science, Kuwait University, Safat, Kuwait
Pages 189-210 | Received 04 Apr 2012, Accepted 11 Oct 2012, Published online: 18 Feb 2013
 
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Abstract

The results of the studies carried out in our laboratories during the last 15 years, aimed at developing green methodologies for the synthesis of polyfunctionalized heteroaromatic substances, are surveyed. The results of the investigations demonstrate that green methodologies are not only less hazard than classical preparative methods but they also are more efficient and economical. For example, short reaction times and higher yields are observed for reactions in which conventional heating is replaced by microwave or ultrasound irradiation. The implementation of multicomponent reactions in green preparative routes also reduces the cost of carrying out the reactions because multiple separation and crystallization steps are avoided. In general, by employing the new green methodologies we have been able to produce a large number of polyfunctional aromatic substances in a highly efficient manner.

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