Multistep soluble polymer-supported, microwave-assisted synthesis of quinoxalines

Abstract

A multistep liquid-phase, polymer-supported, microwave-assisted synthesis of quinoxalines on polyethylene glycol, PEG-4500, is demonstrated. The usage of microwave energy to accelerate organic reactions reduces reaction time from hours (under reflux) to only minutes. The solution-phase chemistry on soluble polyethylene glycol, PEG, support facilitates the use of microwave energy (since PEG easily absorbs microwaves) and avoids the silica gel chromatography purifications of intermediate compounds, supporting parallel, combinatorial, and ultimately automated syntheses.

Keywords:

• quinoxalines
• microwave organic synthesis
• liquid-phase synthesis
• polymer-supported synthesis

Acknowledgements

Farid Fouad would like to thank Professor Robert Twieg at the Department of Chemistry and Biochemistry, Kent State University, for providing his lab facility to carry out this work.