A solvent-free synthesis of 1-(4-chlorophenyl)pyrazolidin-3-one in a ball mill

ABSTRACT

An easy, solvent-free method for the synthesis of 1-(4-chlorophenyl)pyrazolidin-3-one has been achieved by grinding 4-chlorophenyl hydrazine and methyl acrylate in the presence of base in a ball mill. A systematic investigation of the reaction has been made in order to study the various factors affecting the reaction.

GRAPHICAL ABSTRACT

KEYWORDS:

• Solvent-free
• ball mill
• 1-(4-chlorophenyl)pyrazolidin-3-one
• 4-chlorophenyl hydrazine
• methyl acrylate

Disclosure statement

No potential conflict of interest was reported by the authors.

Notes on contributors

Xiong Zhang is working at the School of Science and Technology, Zhejiang International Studies University. His research has focused on green chemistry.

Biao Wang is studying as a master candidate in the College of Chemical Engineering, Zhejiang University of Technology. His research has focused on the asymmetric catalysis and green chemistry.

Binbin Zhang is studying as a master candidate in the College of Chemical Engineering, Zhejiang University of Technology. His research has focused on green chemistry.

Yifeng Wang is working at College of Chemical Engineering, Zhejiang University of Technology. His research has focused on the asymmetric catalysis and green chemistry.

Additional information

Funding

We gratefully acknowledge the funds for Green Pesticides 2011 Cooperative Innovation Center of Zhejiang Province.