Abstract
Purpose: Central nervous system (CNS) prophylaxis in the treatment of childhood acute lymphoblastic leukaemia (ALL) is routinely achieved through intrathecal chemotherapy (ITC). The presence of high level language deficits in older children who received CNS-directed ITC for ALL in early childhood is yet to be elucidated, with previous research suggesting that high level language deficits may appear later in ALL survivors’ development at an age when these skills typically emerge.
Method: A test battery covering foundational language skills and higher-order language skills was administered to five participants (aged 10–15 years) with a history of ITC for ALL. Conversion of each child’s language performance scores to z scores allowed for clinical interpretation of data across the language areas tested.
Result: Foundational language skills were, in general, of no clinical concern. Three of the five children presented with clinically impaired language skills in areas including resolving ambiguity, making inferences and composing novel sentences. Performance variation between the participants and within the individual participants was noted.
Conclusion: Given the importance of early adolescent language abilities to academic and social development in late primary and secondary schooling, these preliminary findings suggest further research into emerging adolescent language abilities following ITC for ALL is warranted.
Acknowledgements
The authors wish to thank the families of the children who participated in the research as well as staff at the Royal Children’s Hospital, Brisbane for their support of the study. The authors also wish to thank the valued input from Dr. Cristina Romani from the School of Life and Health Sciences, Aston University, Birmingham, United Kingdom. The research was supported financially by the Cancer Council Queensland (Grant 51145). This article is a modified version of Jaycie Bohan’s fourth year Speech Pathology student’s Honours Class I thesis under the supervision of Dr. Fiona Lewis.
Declaration of interest
The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.
Supplementary material
Supplemental data for this article can be accessed at http://dx.doi.org/10.1080/17549507.2017.1309066