![Sample our Bioscience journals, sign in here to start your access, Latest two full volumes FREE to you for 14 days]({"type":"image" , "src" : "/sda/5925/TOC-Subject-Sample-2021-Bioscience.jpg"})
Summary
It has been found that a certain group of individuals fail to release, or release only very small amounts of plasminogen activator on exposure to a standardized stimulus (poor responders).
For measuring the fibrinolytic response or capacity, venous occlusion of the limbs is a rather simple method, without potential sideeffects, which makes it suitable for routine clinical practice.
The fibrinolytic activity or the blood obtained from the occluded arm proved to be 3 to 4-fold that of blood from the occluded leg, with a close correlation between both values.
A strictly standardized technique must be applied to obtain reproducible results.
A low response is observed with advancing pregnancy, in obesity, diabetes and in 38 % of patients with recurrent venous thrombosis. The response in Takayasu’s disease is poor or absent.
Release assays with vasopressin (VP) and with a synthetic derivative (DDAVP), even moreactive than VP but devoid of side-effects, showed an impaired fibrinolytic response in patients with thrombotic disease. Further studies on the response to DDAVP in various clinical materials are desirable