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Summary
Between 1980 and 1985, 11 children (8 boys, 3 girls aged between 18 months and 16 years) with poor prognosis ALL (Acute Lymphoblastic Leukaemia) were treated with ablative therapy and allogeneic bone marrow transplantation. Six patients (55 %) are alive at the time of evaluation , one died in aplasia, two died of interstitial pneumonia and two died of bone marrow relapse.
The median time to recover a neutrophil count of 0.5 x 109/1 was 19 days. The total number of lymphocytes reached normal values after 6 months. The percentage of OKT3 cells (mature T lymphocytes) was slightly depressed during the first 3 months. For at least 9 months, the number of OKT4 (helper lymphocytes) was low with a normal number of OKT8 (suppressor lymphocytes) resulting in an OKT4/OKT8 inverted ratio.
As far as B lymphocytes function was concerned, there was a moderate decrease of the immunoglobulin levels. Normal values were obtained after 3 months for IgG, 6 months for IgA and IgM.
All the immunological parameters tested returned to normal within one year after the bone marrow transplantation.